Clinical Research will have to change significantly over the next few years, in order to be able to address already existing and future expectations of patients / customers, novel challenges to the health care system, and legal requirements. Co-Creation, including the “end users / patients” from the very beginning of a clinical development program, as well as “Design Thinking” are among some of the more innovative approaches being added to our Research Tool Kits. Patients, in the near-term future, will be much more empowered and incentivised to share their personal health data, potentially via using blockchain technology and smart contracts. Most likely, the focus will – over all – shift from traditional pharmacological treatments to more holistic therapies, among others including functional foods, i.e. nutriceuticals and “digital therapeutics”.